The Desktop could be corrupted, or, a corrupted monitor calibration file could have been created. 

To delete desktop and qcsetup.cnf files:

Depending on the version of your software, the desktop

(QC*.DAT files) and qcsetup.cnf files are located in :

In Colortools v3.X

  C:Program FilesDatacolorColortoolsTMPQC*.DAT

  C:Program FilesDatacolorColortoolsqcsetup.cnf

In Datacolor Tools v.1.X

  C:Documents and SettingsAll UsersApplication DataDatacolorToolsTools_AppUser_XXXQC*.DAT  where XXX is the name of your user

C:Documents and SettingsAll UsersApplication DataDatacolorToolsTools_Globalqcsetup.cnf

To delete the corrupted monitor calibration file, in Datacolor Tools, delete the following folder and sub-folders with Windows Explorer:

C:Documents and SettingsAll UsersApplication DataDatacolorENVISION

Note:

You can also try adding DatacolorTools.exe and Form Editor as an exception to DEP settings

If you need to uninstall TOOLS, use Add/Remove Program and then renamme the Datacolor folders.

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19. Walmart Process for Datacolor Tools 2.0
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37. How do I export information from my template in Datacolor Tools 2.x to Excel
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