The Desktop could be corrupted, or, a corrupted monitor calibration file could have been created.
To delete desktop and qcsetup.cnf files:
Depending on the version of your software, the desktop
(QC*.DAT files) and qcsetup.cnf files are located in :
In Colortools v3.X
In Datacolor Tools v.1.X
C:Documents and SettingsAll UsersApplication DataDatacolorToolsTools_AppUser_XXXQC*.DAT where XXX is the name of your user
C:Documents and SettingsAll UsersApplication DataDatacolorToolsTools_Globalqcsetup.cnf
To delete the corrupted monitor calibration file, in Datacolor Tools, delete the following folder and sub-folders with Windows Explorer:
C:Documents and SettingsAll UsersApplication DataDatacolorENVISION
You can also try adding DatacolorTools.exe and Form Editor as an exception to DEP settings
If you need to uninstall TOOLS, use Add/Remove Program and then renamme the Datacolor folders.